sub:provenance {
beldoc: dce:description "Approximately 61,000 statements." ;
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
dce:title "BEL Framework Large Corpus Document" ;
pav:authoredBy sub:_4 ;
pav:version "20131211" .
sub:_3 prov:value "It remains to be determined what the role of Ser-62 phosphorylation is in promoter selection or whether the phosphorylation is the consequence of targeting MYC to specific DNA sequences. Furthermore MYC mutated at Thr-58 fails to activate the expression of BIM, a proapoptotic BH3-only BCL2 family member, resulting in reduced apoptosis and enhanced tumorigenesis (38). Although MYC stimulates apoptosis by regulating many different genes (39, 40), MYC-stimulated expression of BIM is particularly relevant for repression of tumor development (41). BIM functions as a tumor suppressor, at least in MYC-driven B cell leukemia. This is independent of the status of the p53 tumor suppressor pathway that is viewed as an important mediator of MYC-induced apoptosis (39, 40)." ;
prov:wasQuotedFrom pubmed:16987807 .
sub:_4 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:16987807 ;
prov:wasDerivedFrom beldoc: ,
sub:_3 .
}