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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#_3 http://www.w3.org/ns/prov#value Endothelin has been implicated in the pathogenesisof ischemic heart disease and congestive heart failure. The aims were toquantify endothelin type A (ETA) and type B (ETB) receptor mRNA levels in humancoronary arteries from patients with ischemic heart disease, congestive heartfailure and controls using real-time polymerase chain reaction (real-time PCR).In addition, the suitability of organ culture as a model mimicking endothelinreceptor changes in cardiovascular disease was evaluated by in vitropharmacology and real-time PCR. Endothelin ETA and ETB receptor mRNA levels weresignificantly higher in arteries from patients with ischemic heart disease(0.23+/-0.04 and 0.35+/-0.06) as compared to congestive heart failure(0.09+/-0.02 and 0.07+/-0.01) and controls (0.08+/-0.02 and 0.08+/-0.01). Afterorgan culture, the endothelin ETB receptor mRNA levels were elevated, and thesarafotoxin 6c-induced vasoconstriction was more efficacious. 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