@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:3180;
    a RNA: .
  
  sub:_2 occursIn: obo:UBERON_0001621, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject go:0001666;
    a rdf:Statement .
  
  sub:assertion rdfs:label "bp(GOBP:\"response to hypoxia\") -> r(HGNC:EDNRB)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "Endothelin has been implicated in the pathogenesisof ischemic heart disease and congestive heart failure. The aims were toquantify endothelin type A (ETA) and type B (ETB) receptor mRNA levels in humancoronary arteries from patients with ischemic heart disease, congestive heartfailure and controls using real-time polymerase chain reaction (real-time PCR).In addition, the suitability of organ culture as a model mimicking endothelinreceptor changes in cardiovascular disease was evaluated by in vitropharmacology and real-time PCR. Endothelin ETA and ETB receptor mRNA levels weresignificantly higher in arteries from patients with ischemic heart disease(0.23+/-0.04 and 0.35+/-0.06) as compared to congestive heart failure(0.09+/-0.02 and 0.07+/-0.01) and controls (0.08+/-0.02 and 0.08+/-0.01). Afterorgan culture, the endothelin ETB receptor mRNA levels were elevated, and thesarafotoxin 6c-induced vasoconstriction was more efficacious. Increasedendothelin receptor activity may contribute to the increased vascular tone anddevelopment of atherosclerotic disease in ischemic heart disease inman.";
    prov:wasQuotedFrom pubmed:14729387 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:14729387;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dcterms:created "2014-07-03T14:32:15.055+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}