. . . . . . . . . . . . "bp(GOBP:\"response to hypoxia\") -> r(HGNC:EDNRB)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Endothelin has been implicated in the pathogenesisof ischemic heart disease and congestive heart failure. The aims were toquantify endothelin type A (ETA) and type B (ETB) receptor mRNA levels in humancoronary arteries from patients with ischemic heart disease, congestive heartfailure and controls using real-time polymerase chain reaction (real-time PCR).In addition, the suitability of organ culture as a model mimicking endothelinreceptor changes in cardiovascular disease was evaluated by in vitropharmacology and real-time PCR. Endothelin ETA and ETB receptor mRNA levels weresignificantly higher in arteries from patients with ischemic heart disease(0.23+/-0.04 and 0.35+/-0.06) as compared to congestive heart failure(0.09+/-0.02 and 0.07+/-0.01) and controls (0.08+/-0.02 and 0.08+/-0.01). Afterorgan culture, the endothelin ETB receptor mRNA levels were elevated, and thesarafotoxin 6c-induced vasoconstriction was more efficacious. Increasedendothelin receptor activity may contribute to the increased vascular tone anddevelopment of atherosclerotic disease in ischemic heart disease inman." . . "Selventa" . . . . "2014-07-03T14:32:15.055+02:00"^^ . . .