[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#_1", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3180" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#_2", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://purl.obolibrary.org/obo/UBERON_0001621" }, { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#_1" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://amigo.geneontology.org/amigo/term/GO:0001666" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "bp(GOBP:\"response to hypoxia\") -> r(HGNC:EDNRB)" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#_4" } ], "http://purl.org/pav/version" : [ { "@value" : "20131211" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#_3", "http://www.w3.org/ns/prov#value" : [ { "@value" : "Endothelin has been implicated in the pathogenesisof ischemic heart disease and congestive heart failure. The aims were toquantify endothelin type A (ETA) and type B (ETB) receptor mRNA levels in humancoronary arteries from patients with ischemic heart disease, congestive heartfailure and controls using real-time polymerase chain reaction (real-time PCR).In addition, the suitability of organ culture as a model mimicking endothelinreceptor changes in cardiovascular disease was evaluated by in vitropharmacology and real-time PCR. Endothelin ETA and ETB receptor mRNA levels weresignificantly higher in arteries from patients with ischemic heart disease(0.23+/-0.04 and 0.35+/-0.06) as compared to congestive heart failure(0.09+/-0.02 and 0.07+/-0.01) and controls (0.08+/-0.02 and 0.08+/-0.01). Afterorgan culture, the endothelin ETB receptor mRNA levels were elevated, and thesarafotoxin 6c-induced vasoconstriction was more efficacious. Increasedendothelin receptor activity may contribute to the increased vascular tone anddevelopment of atherosclerotic disease in ischemic heart disease inman." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/14729387" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#_4", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/14729387" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#_3" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:32:15.055+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAd7vn0TcpDUteluQNNdjGvr-5Oq-Sz_cTYbQlIkPSAx8#pubinfo" } ]