http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#Head http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#assertion http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#provenance http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#assertion http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:96820 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000448 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_1 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=8228 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:pioglitazone) -> r(MGI:Lpl) http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_3 http://www.w3.org/ns/prov#value Lipoprotein lipase (LPL), a key enzyme for triglyceride hydrolysis, is an insulin-dependent enzyme and mainly synthesized in white adipose tissue (WAT) and skeletal muscles (SM). To explore how pioglitazone, an enhancer of insulin action, affects LPL synthesis, we examined the effect of pioglitazone on LPL mRNA levels in WAT or SM of brown adipose tissue (BAT)-deficient mice, which develop insulin resistance and hypertriglyceridemia. Both LPL mRNA of WAT and SM were halved in BAT-deficient mice. Pioglitazone increased LPL mRNA in WAT by 8-fold, which was substantially associated with a 4-fold increase of peroxisome proliferator activated receptor (PPAR)-gamma mRNA (r=0.97,p<0.0001), whereas pioglitazone did not affect LPL mRNA in SM. These results suggest that pioglitazone exclusively increases LPL production in WAT via stimulation of PPAR-gamma synthesis. Since pioglitazone does not affect LPL production in SM, this would contribute to prevent the development of insulin resistance due to lipotoxicity. http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12732191 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12732191 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#_3 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA http://purl.org/dc/terms/created 2014-07-03T14:32:01.866+02:00 http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAd6X9uTzleze-3gVStn4ADi2Jor3ErUiwYqFK-VmZ_YA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234