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[Failure to cleave the prelamin A 'tail', due to mutations in either prelamin A or ZMPSTE24, results in a permanently prenylated form of prelamin A that underlies the premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) and related progeroid disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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