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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps#_3 http://www.w3.org/ns/prov#value Thus, we have cloned the TASK-2 promoter, demonstrated that its transcriptional activity is dependent upon pO(2), shown that deletion of overlapping consensus binding sites for NF-kappaB/Elk-1 ablates this O(2) sensitivity, and proved that Elk-1 binds preferentially to this site. Furthermore, the consequences of chronic hypoxia on natively expressed TASK-2 are decreased steady-state mRNA and cell depolarization showing that TASK-2 contributes to the excitability of this important lung cell type. http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16168386 http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16168386 http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps#_3 http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps http://purl.org/dc/terms/created 2014-07-03T14:32:50.347+02:00 http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAcv71T9JDj5PilfFbMa_A7VBgQmYs-NVTmu0iLEwAgps http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234