[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#_1", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.informatics.jax.org/marker/MGI:1859147" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.informatics.jax.org/marker/MGI:96556" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#_3", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://purl.obolibrary.org/obo/CL_0000893" }, { "@id" : "http://purl.obolibrary.org/obo/UBERON_0002106" }, { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#_2" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/decreases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "p(MGI:Batf) -| r(MGI:Il4)" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#_5" } ], "http://purl.org/pav/version" : [ { "@value" : "20131211" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#_4", "http://www.w3.org/ns/prov#value" : [ { "@value" : "To examine how BATF-mediated negative control of AP-1 activity influences specific transitions in thymic T cell development, the p56lck proximal promoter was used to drive expression of an HA Ag-tagged BATF protein in mice. Two founder animals positive for the transgene were bred to generate the FVB-lck line 2 and FVB-lck line 4 mice used in these studies (Fig. 1A). To determine whether the overexpression of BATF influences cytokine gene expression, thymocytes and splenocytes from wild-type and transgenic FVB-lck line 2 littermates were stimulated in vitro with plate-bound anti-CD3{epsilon} mAb. Total RNA was isolated after 24 h, and RPA was performed. The induction of IL-2, IL-4, IL-5, IL-10, and IL-13 mRNA by transgenic thymocytes is impaired relative to that in wild-type controls, while the expression of IL-6 and IFN-{gamma} mRNA is comparable (Fig. 2A). Transgenic splenocytes showed reduced expression of IL-4 and IL-5 and enhanced expression of IL-2 (Fig. 2A). The RPA was repeated with RNA prepared from FVB-lck line 4 animals, and similar results were obtained (data not shown)." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12594265" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#_5", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12594265" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#_4" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:31:59.146+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RActBdWz8OCSS719dKSzhLsUQ3BvS7NB-00o2_AIaA0x0#pubinfo" } ]