sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_5 ; pav:version "20131211" . sub:_4prov:value "{Modeled as TP63 and not taof because the 'dominant negative' TP63 lacking a transcriptional activation domain also activates the gene - SE} We determined that the trans-activator (TA) isoforms of p63 activate MFGE8 transcription though a p53/p63 motif at -370, which was confirmed by a chromatin immunoprecipitation experiment. Upon siRNA-mediated p63 silencing in a squamous cell carcinoma line, MFG-E8 production decreased to diminish Saos-2 cell adhesion. Interestingly, the DeltaN-p63 isoform lacking the TA domain enhanced the MFGE8-activating function of TA-p63" ; prov:wasQuotedFrompubmed:17637751 . sub:_5rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:17637751 ; prov:wasDerivedFrombeldoc: , sub:_4 . }