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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc#_5 http://www.w3.org/ns/prov#value These results imply that FRS2 and Shp2 are in a BDNF signaling pathway. Shp2 is required for complete MAPK activation by BDNF, as expression of a dominant negative Shp2 in cells attenuates BDNF-induced activation of MAPK. Moreover, expression of a dominant negative Shp2 attenuates Ras activation showing that the protein tyrosine phosphatase is required for complete activation of MAPKs by BDNF. In conclusion, Shp2 regulates BDNF signaling through the MAPK pathway by regulating either Ras directly or alternatively, by signaling components upstream of Ras. http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16573649 http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16573649 http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc#_5 http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc http://purl.org/dc/terms/created 2014-07-03T14:32:59.037+02:00 http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAco5hUKjQD3TDcW5biyZirpMXGmmL5jrIl-4V40OYzRc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234