http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#Head http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#assertion http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#provenance http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#assertion http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6018 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_2 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0009251 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_2 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_1 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:IL6) -> kin(complex(SCOMP:"p85/p110 PI3Kinase Complex")) http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_4 http://www.w3.org/ns/prov#value IL-6 treatment led to activation of the mitogen-activated protein kinase (MAPK) and the phosphatidylinositol 3'-kinase (PI3K) pathways. Inhibition of MAPK or PI3K activity reversed IL-6- and oncostatin M-stimulated migration. For transient transfections, plasmids were introduced into the cells using Superfect transfection reagent (Qiagen). A HA-tagged MAPK (Erk2) construct (kindly provided by M. El-Shemerly and Y. Nagamine; Friedrich Miescher Institute, Basel, Switzerland) was cotransfected with a DN EGF receptor construct lacking 533 COOH-terminal amino acids MAPK kinase inhibitors PD98059 (20 uM; New England Biolabs) or UO126 (50 uM; Promega, Madison, WI PD98059, which is known to specifically inhibit the ERK-activating kinase MEK1, has been widely used to assess the effects of dampening ERK activation. MEK inhibitor UO126 (Promega, MEK Inhibitor U0126 is a chemically synthesized organic compound that inhibits activation of MAPK (ERK 1/2) by inhibiting the kinase activity of MAP Kinase Kinase (MAPKK or MEK 1/2). http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11196191 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11196191 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#_4 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU http://purl.org/dc/terms/created 2014-07-03T14:31:39.817+02:00 http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAchhUlX8-bXqvxGre5FBYNMhxHFh0QE12TJtQsC-loOU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234