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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk#_5 http://www.w3.org/ns/prov#value In this paper we refine our analysis through the use of FOXO3a chromatin immunoprecipitation (ChIP) microarrays. ChIP microarray results reveal urokinase plasminogen activator (uPA) as a putative novel target of FOXO3a in breast epithelial and breast cancer cell lines. We further show that uPA down-regulation after GC treatment requires serum and GC regulated kinase-1-mediated inactivation of FOXO3a activity. ChIP and luciferase assays confirm that FOXO3a can both occupy and transactivate the uPA promoter. http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18239069 http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18239069 http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk#_5 http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk http://purl.org/dc/terms/created 2014-07-03T14:33:16.156+02:00 http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAceEBMbujN2M0_fLEmOXEhWJ11uVnCVb9I5IzTsxL4gk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234