http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#Head http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#assertion http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#provenance http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-complexes/Nfkb%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_1 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-complexes/Nfkb%20Complex http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:103573 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D008264 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_2 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_1 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#assertion http://www.w3.org/2000/01/rdf-schema#label tscript(complex(NCM:"Nfkb Complex")) => r(MGI:Cebpd) http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_4 http://www.w3.org/ns/prov#value Pharmacological inhibition of NF-kappaB blocked LPS-induced Cebpd transcription (Fig. 1d), and LPS-induced Cebpd mRNA (Fig. 1d) and protein (Fig. 1e) quantities were substantially increased in Atf3-null macrophages. Taken together, these data demonstrate that LPS-induced transcription of Cebpd is absolutely dependent on NFkappaB, and that NFkappaB-dependent Cebpd mRNA production is attenuated by ATF3. ChIP analysis demonstrated rapid and transient recruitment of Rel to the promoter of the Cebpd gene; maximal binding was seen 1 hr after stimulation with LPS (Fig. 1f). By contrast, LPS-stimulated ATF3 binding to the promoter of the Cebpd gene (over basal amounts) occurred after 3 h and was sustained (Fig. 1f). http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19270711 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19270711 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#_4 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw http://purl.org/dc/terms/created 2014-07-03T14:30:54.708+02:00 http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234