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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s#_4 http://www.w3.org/ns/prov#value Here, we describe a TCR stimulation-induced Ser/Thr phosphorylation event on PKCtheta that takes place simultaneously with its recruitment to cellular membranes and which can be detected as an electrophoretic mobility shift. By analyzing Ser and Thr point mutants, we find that phosphorylation of Ser-695 in the hydrophobic motif is one, but not the only residue involved in the mobility shift. Interestingly, Ser-695 appears to be required to trigger further phosphorylation events at adjacent Thr-692 and Thr-703 residues, which also participate in the mobility shift. We show that phosphorylation at these residues is not due to auto-phosphorylation, but requires instead Src family kinase and phosphatidylinositol 3-kinase (PI3K) activities. http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14725789 http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14725789 http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s#_4 http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s#pubinfo http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s http://purl.org/dc/terms/created 2014-07-03T14:32:15.005+02:00 http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAc8HU6yGMwa08qo-2p5FrVya5r61K7upZBzsvnOcae0s http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234