@prefix dcterms: .
@prefix this: .
@prefix sub: .
@prefix beldoc: .
@prefix rdfs: .
@prefix rdf: .
@prefix xsd: .
@prefix dce: .
@prefix pav: .
@prefix np: .
@prefix belv: .
@prefix prov: .
@prefix go: .
@prefix scomp: .
@prefix ProteinComplex: .
@prefix hasAgent: .
@prefix mgi: .
@prefix proteinModification: .
@prefix psimod: .
@prefix obo: .
@prefix occursIn: .
@prefix species: .
@prefix pubmed: .
@prefix orcid: .
sub:Head {
this: np:hasAssertion sub:assertion;
np:hasProvenance sub:provenance;
np:hasPublicationInfo sub:pubinfo;
a np:Nanopublication .
}
sub:assertion {
scomp:p85%2Fp110%20PI3Kinase%20Complex a ProteinComplex: .
sub:_1 hasAgent: scomp:p85%2Fp110%20PI3Kinase%20Complex;
a go:0016301 .
sub:_2 belv:variantOf mgi:97601;
a proteinModification:, psimod:00696 .
sub:_3 occursIn: obo:CL_0000542, species:10090;
rdf:object sub:_2;
rdf:predicate belv:increases;
rdf:subject sub:_1;
a rdf:Statement .
sub:assertion rdfs:label "kin(complex(SCOMP:\"p85/p110 PI3Kinase Complex\")) -> p(MGI:Prkcq,pmod(P,S,695))" .
}
sub:provenance {
beldoc: dce:description "Approximately 61,000 statements.";
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
dce:title "BEL Framework Large Corpus Document";
pav:authoredBy sub:_5;
pav:version "20131211" .
sub:_4 prov:value "Here, we describe a TCR stimulation-induced Ser/Thr phosphorylation event on PKCtheta that takes place simultaneously with its recruitment to cellular membranes and which can be detected as an electrophoretic mobility shift. By analyzing Ser and Thr point mutants, we find that phosphorylation of Ser-695 in the hydrophobic motif is one, but not the only residue involved in the mobility shift. Interestingly, Ser-695 appears to be required to trigger further phosphorylation events at adjacent Thr-692 and Thr-703 residues, which also participate in the mobility shift. We show that phosphorylation at these residues is not due to auto-phosphorylation, but requires instead Src family kinase and phosphatidylinositol 3-kinase (PI3K) activities. ";
prov:wasQuotedFrom pubmed:14725789 .
sub:_5 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:14725789;
prov:wasDerivedFrom beldoc:, sub:_4 .
}
sub:pubinfo {
this: dcterms:created "2014-07-03T14:32:15.005+02:00"^^xsd:dateTime;
pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}