sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "Pharmacological inhibition of NF-kappaB blocked LPS-induced Cebpd transcription (Fig. 1d), and LPS-induced Cebpd mRNA (Fig. 1d) and protein (Fig. 1e) quantities were substantially increased in Atf3-null macrophages. Taken together, these data demonstrate that LPS-induced transcription of Cebpd is absolutely dependent on NFkappaB, and that NFkappaB-dependent Cebpd mRNA production is attenuated by ATF3. ChIP analysis demonstrated rapid and transient recruitment of Rel to the promoter of the Cebpd gene; maximal binding was seen 1 hr after stimulation with LPS (Fig. 1f). By contrast, LPS-stimulated ATF3 binding to the promoter of the Cebpd  gene (over basal amounts) occurred after 3 h and was sustained (Fig. 1f). " ;
    prov:wasQuotedFrom pubmed:19270711 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:19270711 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}