sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "20131211" .
  sub:_5 prov:value "Figure 2. A schematic diagram shows the cellular signalling pathway by which ENaC is regulated by the hormones aldosterone and insulin. The effect of aldosterone and insulin is mediated via a phosphatidylinositol 3-kinase (PI3K) and phosphoinositide-dependent protein kinase (PDK) pathway, which activates serum and glucocorticoid-dependent protein kinase (Sgk1) and protein kinase B (Akt1). Both Sgk1 and Akt1 phosphorylate Nedd4-2. The phosphorylated form of Nedd4-2 interacts with 14-3-3, preventing it from binding to and inducing ubiquitination of ENaC. " ;
    prov:wasQuotedFrom pubmed:18197893 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:18197893 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}