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V,274,F
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http://semanticscience.org/resource/SIO_000139
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http://purl.obolibrary.org/obo/RO_0002204
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p(HGNC:TP53,sub(V,274,F)) =| tscript(p(HGNC:TP53))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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In these experiments p53â??223Leu was as active as wild-type p53 in transactivation of the reporter construct, whereas p53â??274Phe had no detectable activity (Fig. 4b). Coexpression of p53â??274Phe inhibited transactivation by p53â??223Leu, thus correlating with the above-described effects of this mutant on growth-inhibitory activity of p53â??223Leu. The lack of detectable transactivation activity of p53â??274Phe suggests that the toxicity of this protein to 10(1) cells is mediated not through p21.
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Selventa
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2014-07-03T14:32:02.723+02:00
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