http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#Head http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#assertion http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#provenance http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#assertion http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/C1q%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://amigo.geneontology.org/amigo/term/GO:0006909 http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/C1q%20Complex http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#assertion http://www.w3.org/2000/01/rdf-schema#label complex(SCOMP:"C1q Complex") => bp(GOBP:phagocytosis) http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_2 http://www.w3.org/ns/prov#value Removal of apoptotic cells is essential for maintenance of tissue homeostasis, organogenesis, remodeling, development, and maintenance of the immune system, protection against neoplasia, and resolution of inflammation. The mechanisms of this removal involve recognition of the apoptotic cell surface and initiation of phagocytic uptake into a variety of cell types. Here we provide evidence that C1q and mannose binding lectin (MBL), a member of the collectin family of proteins, bind to apoptotic cells and stimulate ingestion of these by ligation on the phagocyte surface of the multifunctional protein, calreticulin (also known as the cC1qR), which in turn is bound to the endocytic receptor protein CD91, also known as the alpha-2-macroglobulin receptor. Use of these proteins provides another example of apoptotic cell clearance mediated by pattern recognition molecules of the innate immune system. Ingestion of the apoptotic cells through calreticulin/CD91 stimulation is further shown to involve the process of macropinocytosis, implicated as a primitive and relatively nonselective uptake mechanism for C1q- and MBL-enhanced engulfment of whole, intact apoptotic cells, as well as cell debris and foreign organisms to which these molecules may bind. http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11560994 http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11560994 http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#_2 http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4 http://purl.org/dc/terms/created 2014-07-03T14:31:43.633+02:00 http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAc13-yadxbSV0nlAW0FbvWnWA-zVq-eXVAn0xwKqEau4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234