http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#Head http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#assertion http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#provenance http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#assertion http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12680 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_2 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2514 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#assertion http://www.w3.org/2000/01/rdf-schema#label complex(p(HGNC:CTNNB1),g(HGNC:VEGFA)) http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_3 http://www.w3.org/ns/prov#value To determine whether activation of the Wnt pathway directly up-regulates the VEGF promoter, an oncogenic ß-cateninS37A was transfected with the 2.8-kb VEGF-pGL2 reporter into HeLa cells. A critical serine phosphorylation site at amino acid 37 that ordinarily targets ß-catenin for degradation has been mutated (10) . Fig. 1D. Citation illustrates a linear dose response to the effects of ß-cateninS37A. The peak response was observed when 1.25 µg of expression vector was cotransfected with 0.75 µg of reporter vector, resulting in a >30-fold stimulation of VEGF promoter activity. In independent studies, HeLa cells were treated with 25 mM LiCl, an inhibitor of GSK-3ß kinase activity. GSK-3ß is a negative regulator of Wnt signaling, and inhibiting GSK-3ß with LiCl resulted in a 2.2-fold increase in VEGF promoter activity. Collectively, these findings indicate that activation of Wnt signaling up-regulates VEGF expression in colonic neoplasia. (from full text) http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11507052 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11507052 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#_3 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4 http://purl.org/dc/terms/created 2014-07-03T14:31:43.199+02:00 http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAbxzRbqzKT_JnESRSlysHlY-EskN0U3dUdOL4u65G-D4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234