sub:assertion {
d:DB00241 dv:ddi-interactor-in dr:DB00241_DB01242 .
d:DB01242 dv:ddi-interactor-in dr:DB00241_DB01242 .
dr:DB00241_DB01242 dct:identifier "drugbank_resource:DB00241_DB01242" ;
dct:title "DDI between Butalbital and Clomipramine - Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants such as clomipramine. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation."@en ;
a dv:Drug-Drug-Interaction ;
rdfs:label "DDI between Butalbital and Clomipramine - Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants such as clomipramine. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation. [drugbank_resource:DB00241_DB01242]"@en .
}