http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#Head http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#assertion http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#provenance http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#assertion http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0001230 http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://purl.bioontology.org/ontology/MSH/D017209 http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0009411 http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GOBP:"response to UV") -> bp(MESHPP:Apoptosis) http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_2 http://www.w3.org/ns/prov#value We show here that the expression of E2F6 was downregulated with a concurrent increase in BRCA1 mRNA and cleaved protein during ultraviolet (UV)-induced apoptosis in human embryonic kidney 293 cells. Moreover, E2F6 overexpression distinctly inhibited UV-induced apoptosis as well as UV-induced increases in BRCA1 expression and cleavage, accompanied with increases of the full-length BRCA1 and BRCA1 nuclear foci. In contrast, knockdown of E2F6 by small interfering RNA had opposite effects. Furthermore, these effects of E2F6 on BRCA1 depended upon the association of E2F6 with BRCA1 via its C-terminus in a UV-triggered manner and upon the transcriptional repression by E2F6 on the BRCA1 promoter. http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17096023 http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17096023 http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#_2 http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw http://purl.org/dc/terms/created 2014-07-03T14:33:06.689+02:00 http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAbfdpZotZLQymHUPLaDX877URYTjW_FA8JNAf7GkKXPw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234