sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "20131211" .
  sub:_5 prov:value "The ability of Tpl2 to regulate COX-2 expression depends on ERK signals that activate p90Rsk and Msk1, which in turn phosphorylate CREB, a key regulator of COX-2 transcription. The ERK phosphorylates p90Rsk at serine-364, 381 and threonine-360, which in turn phosphorylates Creb1 at serine-133 in cells treated by the LPS. The ERK mediated phosphorylation of p90Rsk was abrogated in Tpl2-/- cells. {Tpl2 Official Gene Symbol: MAP3K8, p90Rsk Official Gene Symbol: Rps6ka1, Msk1 Official Gene Symbol: Rps6ka5}" ;
    prov:wasQuotedFrom pubmed:12234923 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12234923 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}