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[Here, we show that the dopamine- and cAMP-regulated phosphoprotein 32 kDa (DARPP-32), a key inhibitor of protein phosphate-1 (PP-1) that regulates CREB phosphorylation, is cleaved by activated calpain in both AD brains and neuronal cells treated with amyloid-? or okadaic acid, a protein phosphatase-2A inhibitor that induces tau hyperphosphorylation and neuronal death.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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