http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#Head http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#assertion http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#provenance http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#assertion http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9395 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0001264 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_1 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/positiveCorrelation http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-diseases/Diabetes http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#assertion http://www.w3.org/2000/01/rdf-schema#label path(SDIS:Diabetes) positiveCorrelation r(HGNC:PRKCB) http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_3 http://www.w3.org/ns/prov#value Moreover, because metformin has protective effects on nondiabetic beta-cells exposed to high glucose or free fatty acid levels, we investigated its direct action on T2D islet cells. Diabetic islets were characterized by reduced insulin content, decreased amount of mature insulin granules, impaired glucose-induced insulin secretion, reduced insulin mRNA expression, and increased apoptosis with enhanced caspase-3 and -8 activity. These alterations were associated with increased oxidative stress, as shown by higher nitrotyrosine concentrations, increased expression of protein kinase C-beta2 and nicotinamide adenine dinucleotide phosphate reduced-oxidase, http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15531508 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15531508 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#_3 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0 http://purl.org/dc/terms/created 2014-07-03T14:32:34.532+02:00 http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAb__6ezvA9FOv9-SaYrq-jE7aOjtmq8E6G0zBaJIzkO0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234