sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_4 ; pav:version "20131211" . sub:_3prov:value "Therefore, we examined the expression of several genes important in lipid metabolism in ATMs from normal diet and high-fat diet mice. Apoe was downregulated in ATMs with high-fat diet. Expression of both adipocyte differentiation–related protein (Adfp) and peroxisome proliferator activation receptor-? (Pparg) were increased in high-fat diet ATMs (Fig. 4A). To determine the functional significance of these findings, we examined the lipid content of ATMs isolated from normal diet–and high-fat diet–fed animals by Nile Red staining. Both macrophage (CD11b+) and nonmacrophage (CD11b?) cells in SVF cultures had Nile Red–positive vesicles; however, ATMs had more pronounced lipid accumulation, especially in obese mice " ; prov:wasQuotedFrompubmed:17192460 . sub:_4rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:17192460 ; prov:wasDerivedFrombeldoc: , sub:_3 . }