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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAbLOI3R2gNEQALEXKW6br1-B69tphFb1cuGqXcHeolWQ#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAbLOI3R2gNEQALEXKW6br1-B69tphFb1cuGqXcHeolWQ#_2 http://purl.org/dc/elements/1.1/identifier C. A. O'Callaghan, Barry M. Brenner http://www.tkuhn.ch/bel2nanopub/RAbLOI3R2gNEQALEXKW6br1-B69tphFb1cuGqXcHeolWQ#_2 http://purl.org/dc/elements/1.1/title C. A. O'Callaghan, Barry M. Brenner http://www.tkuhn.ch/bel2nanopub/RAbLOI3R2gNEQALEXKW6br1-B69tphFb1cuGqXcHeolWQ#_2 http://purl.org/dc/elements/1.1/type Other http://www.tkuhn.ch/bel2nanopub/RAbLOI3R2gNEQALEXKW6br1-B69tphFb1cuGqXcHeolWQ#_3 http://www.w3.org/ns/prov#value The primary insult is damage to the renal vessels from the raised pressure. In the interlobular artery walls, muscle is replaced by sclerotic tissue. The afferent arteriole walls undergo hyalinization - the subintimal deposition of lipids and glycoproteins exuded from plasma. Damage to these resistance vessels exposes the glomerular capillary endothelium to hypertension. This reduces glomerular blood flow and filtration, and promotes proteinuria. 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