sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_8 ;
    pav:version "20131211" .
  sub:_6 dce:identifier "Cardiovascular Physiology Concepts" ;
    dce:title "Cardiovascular Physiology Concepts" ;
    dce:type "Other" .
  sub:_7 prov:value "There are several signal transduction mechanisms that modulate intracellular calcium concentration and therefore the state of vascular tone.  Three different mechanisms will be described here: 1) phosphatidylinositol pathway, 2) Gs-protein-coupled pathway, and 3) nitric oxide-cGMP pathway The phosphatidylinositol pathway (shown to the right) in VSM is similar to that found in the heart.  Norepinephrine (NE) acting via a1-adrenoceptors, angiotensin II (AII) acting via AII receptors, and endothelin-I (ET-1) acting through ETA receptors activate phospholipase C (PL-C) causing the formation of inositol triphosphate (IP3) from phosphatidylinositol (PIP2)." ;
    prov:wasQuotedFrom sub:_6 .
  sub:_8 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource sub:_6 ;
    prov:wasDerivedFrom beldoc: , sub:_7 .
}