. . . . . . . . . . . . . . . . . . . "kin(p(RGD:Gsk3b)) -| tscript(p(RGD:Egr1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Moreover, protein-DNA array studies identified two novel GSK-3-regulated transcription factors, early growth response 1 and Smad3/4, which were oppositely affected by GSK-3alpha or GSK-3beta silencing or inhibition Binding activity of EGR-1-responsive element with EGR-1 was down-regulated by transfection with siRNA for GSK-3{alpha} but up-regulated by siRNA for GSK-3beta compared with the non-targeting siRNA control. Luciferase reporter assays confirmed that the transcriptional activity of EGR-1 was decreased by GSK-3{alpha} siRNA and its dominant negative mutant but increased by GSK-3beta siRNA and its dominant negative mutants (Fig. 4A)." . . "Selventa" . . . . "2014-07-03T14:33:02.725+02:00"^^ . . .