sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_7 ;
    pav:version "20131211" .
  sub:_6 prov:value "Moreover, protein-DNA array studies identified two novel GSK-3-regulated transcription factors, early growth response 1 and Smad3/4, which were oppositely affected by GSK-3alpha or GSK-3beta silencing or inhibition Binding activity of EGR-1-responsive element with EGR-1 was down-regulated by transfection with siRNA for GSK-3{alpha} but up-regulated by siRNA for GSK-3beta compared with the non-targeting siRNA control. Luciferase reporter assays confirmed that the transcriptional activity of EGR-1 was decreased by GSK-3{alpha} siRNA and its dominant negative mutant but increased by GSK-3beta siRNA and its dominant negative mutants (Fig. 4A)." ;
    prov:wasQuotedFrom pubmed:16912034 .
  sub:_7 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:16912034 ;
    prov:wasDerivedFrom beldoc: , sub:_6 .
}