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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAbDAo0LYBALUawO4L6pOrtBls-dY_zglFFP7fdDhOnkY#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAbDAo0LYBALUawO4L6pOrtBls-dY_zglFFP7fdDhOnkY#_2 http://www.w3.org/ns/prov#value The mobilization of Ca2? from intracellular stores leading to a rapid and transient increase in [Ca2? ]i is one of the earliest events stimulated by agonist binding to CCKB/gastrin receptor in many cell types (Rozengurt and Walsh, 2001).The activation of this receptor induces Gaq-mediated stimulation of phospholipase C (PLC) which catalyses the hydrolysis of phosphatidyl inositol 4,5-bisphosphate (PIP2) in the plasma membrane to produce two second messengers: inositol 1,4,5-trisphosphate (ins(1,4,5)P3) and 1,2,-diacylglycerol (DAG) (Exton, 1996). 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