. . . . . . . . . . "a(SCHEM:\"Inositol 1,4,5-trisphosphate\") -> a(SCHEM:Calcium)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "The mobilization of Ca2? from intracellular stores leading to a rapid and transient increase in [Ca2? ]i is one of the earliest events stimulated by agonist binding to CCKB/gastrin receptor in many cell types (Rozengurt and Walsh, 2001).The activation of this receptor induces Gaq-mediated stimulation of phospholipase C (PLC) which catalyses the hydrolysis of phosphatidyl inositol 4,5-bisphosphate (PIP2) in the plasma membrane to produce two second messengers: inositol 1,4,5-trisphosphate (ins(1,4,5)P3) and 1,2,-diacylglycerol (DAG) (Exton, 1996). Ins(1,4,5)P3 binds to its intracellular receptor, a ligand-gated Ca2? channel located in the endoplasmic reticulum, and triggers the release of Ca2? from internal stores (Exton, 1996; Mikoshiba, 1997; Rozengurt, 1998)." . . "Selventa" . . . . "2014-07-03T14:31:45.456+02:00"^^ . . .