sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_3 ;
    pav:version "20131211" .
  sub:_2 prov:value "The mobilization of Ca2? from intracellular stores leading to a rapid and transient increase in [Ca2? ]i is one of the earliest events stimulated by agonist binding to CCKB/gastrin receptor in many cell types (Rozengurt and Walsh, 2001).The activation of this receptor induces Gaq-mediated stimulation of phospholipase C (PLC) which catalyses the hydrolysis of phosphatidyl inositol 4,5-bisphosphate (PIP2) in the plasma membrane to produce two second messengers: inositol 1,4,5-trisphosphate (ins(1,4,5)P3) and 1,2,-diacylglycerol (DAG) (Exton, 1996). Ins(1,4,5)P3 binds to its intracellular receptor, a ligand-gated Ca2? channel located in the endoplasmic reticulum, and triggers the release of Ca2? from internal stores (Exton, 1996; Mikoshiba, 1997; Rozengurt, 1998)." ;
    prov:wasQuotedFrom pubmed:11748587 .
  sub:_3 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11748587 ;
    prov:wasDerivedFrom beldoc: , sub:_2 .
}