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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#_4 http://www.w3.org/ns/prov#value The secreted factor FGF8, which is emanated from the isthmic organizer, is essential for the development of the midbrain and hindbrain (Liu and Joyner, 2001bGo; Nakamura et al., 2005Go; Wurst and Bally-Cuif, 2001Go). Therefore, we sought to dissect the possible relationship between the expression of Lmx1b and that of Fgf8 during mid/hindbrain development at stages prior to E10.5, the stage at which morphological defects in the MHB were first observed in the Lmx1b-/- embryo. In the wild-type embryo, Fgf8 expression was first observed in the presumptive MHB at the 4-somite stage (Fig. 4A). Strikingly, Fgf8 expression was absent in the Lmx1b-/- mutant at this stage (Fig. 4B). By contrast, Fgf8 expression in other regions of the mutant embryo was normal (arrowhead in Fig. 4B), suggesting specific regulation of Fgf8 expression by Lmx1b in the MHB. http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17166916 http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17166916 http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#_4 http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#pubinfo http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k http://purl.org/dc/terms/created 2014-07-03T14:33:07.594+02:00 http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234