@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAbCUQqgE6KFFaYzewF11eANYoBkuytZaZxB0fzFmBL2k#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: mgi:1100513;
    a Protein: .
  
  sub:_2 geneProductOf: mgi:99604;
    a RNA: .
  
  sub:_3 occursIn: obo:UBERON_0005291, species:10090;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(MGI:Lmx1b) -> r(MGI:Fgf8)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "20131211" .
  
  sub:_4 prov:value "The secreted factor FGF8, which is emanated from the isthmic organizer, is essential for the development of the midbrain and hindbrain (Liu and Joyner, 2001bGo; Nakamura et al., 2005Go; Wurst and Bally-Cuif, 2001Go). Therefore, we sought to dissect the possible relationship between the expression of Lmx1b and that of Fgf8 during mid/hindbrain development at stages prior to E10.5, the stage at which morphological defects in the MHB were first observed in the Lmx1b-/- embryo.  In the wild-type embryo, Fgf8 expression was first observed in the presumptive MHB at the 4-somite stage (Fig. 4A). Strikingly, Fgf8 expression was absent in the Lmx1b-/- mutant at this stage (Fig. 4B). By contrast, Fgf8 expression in other regions of the mutant embryo was normal (arrowhead in Fig. 4B), suggesting specific regulation of Fgf8 expression by Lmx1b in the MHB.";
    prov:wasQuotedFrom pubmed:17166916 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:17166916;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:07.594+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}