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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk#_5 http://www.w3.org/ns/prov#value Secondary insulin resistance in liver and adipose tissue Steady-state circulating free fatty acid (FFA) levels represent a balance between FFA production and removal. The acute effects of insulin in lowering FFA levels are due, in large part, to insulin's antilipolytic effects in adipose tissue. In control animals, insulin infusion suppressed FFA levels by approx60% in both 6- and 14-month-old mice (Fig. 4a). This effect was significantly blunted in 6- and 14-month-old MKOfl/fl (P = 0.0089 and P = 0.01, respectively) mice, as well as 14-month-old MKOfl/- mice (P = 0.009), as fatty acid levels in those mice were depressed by only approx30%. http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14625542 http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14625542 http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk#_5 http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk http://purl.org/dc/terms/created 2014-07-03T14:32:12.214+02:00 http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAaFPt2x-phkPG5-xTdQ6NQlcPvPX2mS4mh2nh6O92Gsk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234