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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g#_5 http://www.w3.org/ns/prov#value Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2. http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11294822 http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11294822 http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g#_5 http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g#pubinfo http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g http://purl.org/dc/terms/created 2014-07-03T14:31:41.046+02:00 http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAa95CegkWw9gZjg-Gog0_0zUICV5hnMbN7AcEkL-pK1g http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234