sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_4 ;
    pav:version "20131211" .
  sub:_3 prov:value "Shapiro and colleagues (107) demonstrated that MMP-12-null mice are protected from the development of cigarette smoke-induced emphysema. Infiltrating macrophages in wild-type mice exposed to cigarette smoke might have been attracted by elastin fragments released by MMP-12, as MMP-12 knockout mice did not show evidence of increased alveolar macrophage accumulation due to chronic cigarettes smoke inhalation (124). When exposed to cigarette smoke for 2–3 days, MMP-12-null mice had an attenuated number of lung neutrophils and decreased expression of MIP-2, MIP-1{alpha}, and MMP-9 activity in BAL, suggesting that the MMP-9 response is dependent almost entirely on MMP-12 expression (180). " ;
    prov:wasQuotedFrom pubmed:17615396 .
  sub:_4 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:17615396 ;
    prov:wasDerivedFrom beldoc: , sub:_3 .
}