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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAa-tzbP1_Zem2BfbdUbPN91h68s9WAX0E04JgxMolk8w#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAa-tzbP1_Zem2BfbdUbPN91h68s9WAX0E04JgxMolk8w#_5 http://www.w3.org/ns/prov#value Thus, JAKs are receptor-associated protein tyrosine kinases, which are utilized by leptin receptors to phosphorylate the receptor itself as well as targets such as STAT proteins. These transcription factors are recruited to activated obR/JAK complexes via SH2 and SH3 domains and become activated upon tyrosine phosphorylation. Activation involves dissociation from the receptor and the formation of homo- or heterodimers that translocate to the nucleus and interact with specific DNA elements in the promoters of target genes to regulate gene expression the sequence surrounding Y1138 (YXXQ) in obRb represents a consensus STAT3- binding motif. 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