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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8#_5 http://www.w3.org/ns/prov#value Genomic amplification at 20q11-13 is a common event in human cancers. We isolated a germline translocation breakpoint at 20q11 from a bladder cancer patient. We identified CDC91L1, the gene encoding CDC91L1 (also called phosphatidylinositol glycan class U (PIG-U), a transamidase complex unit in the glycosylphosphatidylinositol (GPI) anchoring pathway), as the only gene whose expression was affected by the translocation. CDC91L1 was amplified and overexpressed in about one-third of bladder cancer cell lines and primary tumors, as well as in oncogenic uroepithelial cells transformed with human papillomavirus (HPV) E7. Forced overexpression of CDC91L1 malignantly transformed NIH3T3 cells in vitro and in vivo. Overexpression of CDC91L1 also resulted in upregulation of the urokinase receptor (uPAR), a GPI-anchored protein, and in turn increased STAT-3 phosphorylation in bladder cancer cells. Our findings suggest that CDC91L1 is an oncogene in bladder cancer, and implicate the GPI anchoring system as a potential oncogenic pathway and therapeutic target in human cancers. Overexpression of CDC91L1 also resulted in upregulation of the urokinase receptor (uPAR), a GPI-anchored protein, and in turn increased STAT-3 phosphorylation in bladder cancer cells. http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15034568 http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15034568 http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8#_5 http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8#pubinfo http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8 http://purl.org/dc/terms/created 2014-07-03T14:32:18.469+02:00 http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA_yA2vwW7Mq_kIFTjrnJyQp7jg3y1Iy5dVEiAyqbdiM8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234