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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA_y4PMUqx6kCP5i8qdiZk-flBGG-ZworxqfacwAnR0Ig#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA_y4PMUqx6kCP5i8qdiZk-flBGG-ZworxqfacwAnR0Ig#_5 http://www.w3.org/ns/prov#value DAF-16 and its mammalian homologues, including FKHR (FOXO1), FKHRL1 (FOXO3a), and AFX (FOXO4) interact directly with IRSs from the IGFBP-1 promoter in a sequence-specific fashion in in vitro assays and in cells. In liver-derived cells, FOXO proteins stimulate the activity of promoters for IGFBP-1, glucose-6 phosphatase, and PEPCK. 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