http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#Head http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#assertion http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#provenance http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#pubinfo http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#assertion http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3229 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_2 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_3 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_3 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/MAPK%20Erk1%2F2%20Family http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0002172 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_2 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_1 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:EGF) -> kin(p(SFAM:"MAPK Erk1/2 Family")) http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_5 http://www.w3.org/ns/prov#value EGF also prevented H2O2-induced disruption of the actin cytoskeleton and the dissociation of occludin and ZO-1 from the actin-rich detergent-insoluble fractions. MEK (MAPK/ERK kinase, where ERK stands for extracellular signal related kinase) inhibitors, PD98059 and U0126, completely blocked these protective effects of EGF on TJs. EGF rapidly increased the levels of phosphorylated MEK (p-MEK) in detergent-soluble fractions and phosphorylated ERK (p-ERK) in detergent-insoluble fractions. p-ERK was colocalized and co-immunoprecipitated with occludin. http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16134968 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16134968 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#_5 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194#pubinfo http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194 http://purl.org/dc/terms/created 2014-07-03T14:32:49.638+02:00 http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA_g6FVOi1a1Aivv089fG6GRFytU3EHm9qjR6PVpb1194 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234