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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#_6 http://www.w3.org/ns/prov#value We show that functional RhoA is required for LPA-, serum-, and AIF4--induced transcriptional activation by SRF and that tw~ other Rho family GTPases, Racl and CDC42Hs, can also potentiate SRF activity.......NIH 3T3 cells were transfected with CAT reporter genes controlled by either two copies of the wild-type c-los SRE, or its derivative SRE.L, which cannot bind TCF, together with expression plasmids producing the activated small GTPases Ras.R12, RhoA.V14, Rac1.V12, or CDC42Hs.......The serum response element (SRE) is a regulatory sequence found in many growth factor-regulated promoters (reviewed by Treisman, 1990). The SRE binds the ubiquitous transcription factor SRF (serum response factor; Norman et al., 1988), which is required for its activity. V12. Coexpression of each of the proteins activated the wild-type SRE in the absence of growth factor stimulation, with an efficiency approaching that of serum stimulation in the case of CDC42Hs (Figure 3A, left). http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/7600583 http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/7600583 http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#_6 http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#pubinfo http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY http://purl.org/dc/terms/created 2014-07-03T14:33:45.753+02:00 http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234