@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA__KI_-vyAZrvf3w1wiwmX3soRw4owyn0K-sZtyLtsaY#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0005525 .
  
  sub:_2 geneProductOf: mgi:1096342;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0042789 .
  
  sub:_4 geneProductOf: mgi:106658;
    a Protein: .
  
  sub:_5 occursIn: obo:CLO_0008172, species:10090;
    rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "gtp(p(MGI:Rhoa)) -> tscript(p(MGI:Srf))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_7;
    pav:version "20131211" .
  
  sub:_6 prov:value "We show that functional RhoA is required for LPA-, serum-, and AIF4--induced transcriptional activation by SRF and that tw~ other Rho family GTPases, Racl and CDC42Hs, can also potentiate SRF activity.......NIH 3T3 cells were transfected with CAT reporter genes controlled by either two copies of the wild-type c-los SRE, or its derivative SRE.L, which cannot bind TCF, together with expression plasmids producing the activated small GTPases Ras.R12, RhoA.V14, Rac1.V12, or CDC42Hs.......The serum response element (SRE) is a regulatory sequence found in many growth factor-regulated promoters (reviewed by Treisman, 1990). The SRE binds the ubiquitous transcription factor SRF (serum response factor; Norman et al., 1988), which is required for its activity. V12. Coexpression of each of the proteins activated the wild-type SRE in the absence of growth factor stimulation, with an efficiency approaching that of serum stimulation in the case of CDC42Hs (Figure 3A, left).";
    prov:wasQuotedFrom pubmed:7600583 .
  
  sub:_7 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:7600583;
    prov:wasDerivedFrom beldoc:, sub:_6 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:45.753+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}