sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_7 ;
    pav:version "20131211" .
  sub:_6 prov:value "We show that functional RhoA is required for LPA-, serum-, and AIF4--induced transcriptional activation by SRF and that tw~ other Rho family GTPases, Racl and CDC42Hs, can also potentiate SRF activity.......NIH 3T3 cells were transfected with CAT reporter genes controlled by either two copies of the wild-type c-los SRE, or its derivative SRE.L, which cannot bind TCF, together with expression plasmids producing the activated small GTPases Ras.R12, RhoA.V14, Rac1.V12, or CDC42Hs.......The serum response element (SRE) is a regulatory sequence found in many growth factor-regulated promoters (reviewed by Treisman, 1990). The SRE binds the ubiquitous transcription factor SRF (serum response factor; Norman et al., 1988), which is required for its activity. V12. Coexpression of each of the proteins activated the wild-type SRE in the absence of growth factor stimulation, with an efficiency approaching that of serum stimulation in the case of CDC42Hs (Figure 3A, left)." ;
    prov:wasQuotedFrom pubmed:7600583 .
  sub:_7 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:7600583 ;
    prov:wasDerivedFrom beldoc: , sub:_6 .
}