. . . . . . . . . . . . . . . . . . "cat(p(HGNC:TLR4)) -> kin(p(HGNC:IRAK1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "CSM-induced activation of TLR-4 has been shown to induce IRAK1 phosphorylation and TRAF6 degradation. An increase in IkB phosphorylation and degradation is also observed which ultimately leads to the translocation of NF-kB (p65) into the nucleus. The ability of cigarette smoke condensate (CSC) to activate NF-kB has also been demonstrated in another study using U937 cells. CSC has been shown to induce the activation of IKK (-a and -b) at 15 minutes post treatment, which resulted in increased phosphorylation of I?-B? at serine 32, resulting in Ik-Ba degradation and subsequent activation of NF-kB [53]." . . "Selventa" . . . . "2014-07-03T14:33:37.403+02:00"^^ . . .