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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y#_5 http://www.w3.org/ns/prov#value Although activation of RAF and AKT is clearly sufficient to repress p27Kip1 expression, these experiments do not address whether the PI3'-kinase-PDK1-AKT and the RAF-MEK- ERK pathways are required for the repression of p27Kip1 in response to mitogenic stimulation or oncogenic transformation. To address this, we used pharmacological inhibitors of the signaling proteins PI3'-kinase (LY294002), mTor (rapamycin), and MEK (PD98059, U0126, or CI-1040) either alone or in combination with one another. PDGF stimulation of quiescent NIH 3T3 cells leads to activation of both the PI3'-kinase- PDK1-AKT and the RAF-MEK-ERK signaling pathways and repression of p27Kip1 expression (Fig. 3A). http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15572689 http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15572689 http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y#_5 http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y#pubinfo http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y http://purl.org/dc/terms/created 2014-07-03T14:30:29.934+02:00 http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA_M9H9l4mZF5_ubWKCi83LtKEls_n5qutSS3V-kdAl8Y http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234