sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.4" .
  sub:_5 prov:value "Although activation of RAF and AKT is clearly sufficient to repress p27Kip1 expression, these experiments do not address whether the PI3'-kinase-PDK1-AKT and the RAF-MEK- ERK pathways are required for the repression of p27Kip1 in response to mitogenic stimulation or oncogenic transformation. To address this, we used pharmacological inhibitors of the signaling proteins PI3'-kinase (LY294002), mTor (rapamycin), and MEK (PD98059, U0126, or CI-1040) either alone or in combination with one another. PDGF stimulation of quiescent NIH 3T3 cells leads to activation of both the PI3'-kinase- PDK1-AKT and the RAF-MEK-ERK signaling pathways and repression of p27Kip1 expression (Fig. 3A)." ;
    prov:wasQuotedFrom pubmed:15572689 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15572689 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}