@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_head {
  this: np:hasAssertion dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_assertion;
    np:hasProvenance dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_provenance;
    np:hasPublicationInfo dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_assertion a np:Assertion .
  
  dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_provenance a np:Provenance .
  
  dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_assertion {
  miriam-gene:4843 a ncit:C16612 .
  
  lld:C0566602 a ncit:C7057 .
  
  dgn-gda:DGN08e2902ba547b90361107bf8d21f74ff sio:SIO_000628 miriam-gene:4843, lld:C0566602;
    a sio:SIO_001121 .
}

dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_provenance {
  dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_assertion dcterms:description
      "[Our results show that: (1) tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, synergically stimulate NO production in cultured cholangiocytes through an increase in NOS2 gene and protein expression; (2) micromolar concentrations of NO inhibit forskolin-stimulated cAMP production by adenylyl cyclase (AC), cyclic adenosine monophosphate (cAMP)-dependent fluid secretion, and cAMP-dependent Cl(-) and HCO(3)(-) transport mediated by cystic fibrosis transmembrane conductance regulator (CFTR) and anion exchanger isoform 2, respectively; (3) cholestatic effects of NO and of proinflammatory cytokines are prevented by NOS-2 inhibitors and by agents (manganese(III)-tetrakis(4-benzoic acid)porphyrin [MnTBAP], urate, trolox) able to block the formation of reactive nitrogen oxide species (RNOS); (4) NOS2 expression is increased significantly in the biliary epithelium of patients with primary sclerosing cholangitis (PSC).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_curated;
    sio:SIO_000772 miriam-pubmed:12612912;
    prov:wasDerivedFrom dgn-void:ctd_human-20130708;
    prov:wasGeneratedBy eco:ECO_0000218 .
  
  dgn-void:ctd_human-20130708 pav:importedOn "2013-07-24"^^xsd:date .
  
  dgn-void:source_evidence_curated a eco:ECO_0000205;
    rdfs:comment "Gene-disease associations manually curated."@en;
    rdfs:label "DisGeNET evidence - CURATED"@en .
}

dgn-np:NP24311.RA_I9BrC46jOxQ_srHmLgyJ_LVLHZ4OlvUm5cDtCnMIzI130_publicationInfo {
  this: dcterms:created "2014-10-02T12:32:09+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}